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Two studies in 20 suggested that about 40% of Ashkenazi Jews originate maternally from just four female founders which are likely of Near-Eastern origin, while the populations of Sephardi and Mizrahi Jewish communities "showed no evidence for a narrow founder effect".Evidence for female founders has been observed in other Jewish populations.A study conducted in 2013 found no evidence of a Khazar origin for Ashkenazi Jews and suggested that "Ashkenazi Jews share the greatest genetic ancestry with other Jewish populations, and among non-Jewish populations, with groups from Europe and the Middle East.No particular similarity of Ashkenazi Jews with populations from the Caucasus is evident, particularly with the populations that most closely represent the Khazar region. Pirooznia, Elhaik advanced the view that the first Ashkenazi populations to speak the Yiddish language came from areas near four villages in Eastern Turkey along the Silk Road whose names derived from the word "Ashkenaz", arguing that Iranian, Greek, Turkish, and Slav populations converted on that travel route before moving to Khazaria, where a small-scale conversion took place.

Scholars such as Harry Ostrer and Raphael Falk believe this may indicate that many Jewish males found new mates from European and other communities in the places where they migrated in the diaspora after fleeing ancient Israel.

Recent studies have been conducted on a large number of genes homologous chromosomes or autosomes (all chromosomes except chromosomes X and Y).

A 2009 study was able to genetically identify individuals with full or partial Ashkenazi Jewish ancestry. Harry Ostrer in his book Legacy: A Genetic History of the Jewish People, summarized his and other work in genetics of the last 20 years, and concluded that all major Jewish groups share a common Middle Eastern origin.

Studies of autosomal DNA, which look at the entire DNA mixture, have become increasingly important as the technology develops.

They show that Jewish populations have tended to form relatively closely related groups in independent communities, with most in a community sharing significant ancestry in common.

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